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| Desired Industry: Biotech |
SpiderID: 8957 |
| Desired Job Location: Cambridge, Massachusetts |
Date Posted: 9/27/2006 |
| Type of Position: Full-Time Permanent |
Availability Date: |
| Desired Wage: |
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U.S. Work Authorization: Yes |
| Job Level: Experienced with over 2 years experience |
Willing to Travel: |
| Highest Degree Attained: Doctoral |
Willing to Relocate: Undecided |
Objective:
A research scientist position to apply my skills in synthetic organic chemistry in the drug discovery and development
Experience:
ArQule Inc., Woburn, MA 2001¡V 2006
Senior Investigator I (promoted, 2005), Investigator II (promoted, 2003), Investigator I
„X Developed over 40 transformations in more than 150 focused libraries
„X Developed novel chemotypes in hit follow-up projects ¡V resulted in 3 series of 2nd lead generation in the research of cardiovascular and metabolic diseases
„X Developed pyrimidine and fused thiazole-pyrimidine chemotypes as P38 and PTK inhibitors
„X Developed in-situ isonitrile formation in parallel synthesis ¡V improved IP positions in drug designs
„X Solved key chemistry problems ¡V successfully salvaged more than 10 projects from failures
„X Expedited multi-parameter chemistry optimization via Design of Experiment (DoE) ¡V reduced development time from regular 2 months to 1 week
NeuroLogic Inc., Maryland, MD 1999 ¡V 2001
Staff Scientist
„X Designed and developed 2 new chemical entities in the treatment of Alzheimer¡¦s disease
o Structure-based design and synthesis of protein kinase C activators as ƒÑ-secreatase promoters ¡V resulted in 2 publications and 1 US patent application
o Independently developed new peptidomimetics as ƒÒ-secreatase inhibitors ¡V 1 US/WO patent
„X Developed more than 15-step practical approach for active pharmaceutical intermediate (API) scale-up ¡V timely delivered API for amyloid-beta studies on transgenic mice
„X Prepared chemistry details for SBIR grant and patent applications
„X Successfully set up chemistry lab from ground zero
POSTDOCTORAL TRAINING
Georgetown University Medical Center, Washington D.C. 1996 ¡V 1999
Postdoctoral fellow with Professor Alan P. Kozikowski
„X Accomplished proof of the concepts ¡V strongly supported renewals of two NCI/NIH grants
„X Developed 3 generations of protein kinase C activators on the structure-based designs ¡V published 6 papers and 2 US/WO patents
„X Discovered novel phosphatidylinositol 3-kinase inhibitors as anticancer agents ¡V published 5 papers and 1 US patent
o Phospholipid conjugate went through pre-clinic study under NIH/RAID program
„X Explored pro-drug type of 1-sphingosine phosphate - improved its solubility for bioassays
o 2 publications
„X Completed more than 20-step scale-up of phosphatidyl inositol ether lipids ¡V quickly delivered high quality API for the preclinical study under NIH/RAID program
Education:
* Ph.D. Organic chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, ShangHai, China, 1996 (with Prof. Yu-Lin Wu)
* M.S. Organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, China (with Prof. Zhengmin Li)
* B.S. Organic Chemistry, NanKai University, Tianjin, China
Affiliations:
American Chemical Society
Skills:
TECHNICAL SKILLS
„X Experienced in the synthesis of diverse organic compounds in solution phase and solid phase chemistry, as well as using Microwave technology
„X Hands on experience in novel compounds characterization with LC-MS, 1D/2D NMR, and purification with prep-TLC, flash column chromatography, AnaLogiX„§ , HPLC
„X Skillful in the application of chemical based software and drug-like molecules designs
„X Quick data interpretation using Pipeline Pilot„§ and Spotfire„§
Additional Information:
5 US patent, and 18 publications since 1997
Candidate Contact Information:
| Name: Lixin Qiao |
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| Street: - |
Phone: 781-704-5396 |
| City: - |
Fax: - |
| State: Massachusetts |
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| Zip: - |
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