Research Scientist Resume

Desired Industry: Biotech	SpiderID: 3181
Desired Job Location: Jersey City, New Jersey	Date Posted: 7/27/2005
Type of Position: Full-Time Permanent	Availability Date: 09/30/05
Desired Wage: 75000
	U.S. Work Authorization: Yes
Job Level: New Grad/Entry Level	Willing to Travel: Yes, Less Than 25%
Highest Degree Attained: Doctoral	Willing to Relocate: Yes

Objective:
Looking for a research scientist position related to design and execution of studies in the area of cancer biology, molecular therapeutics or gene therapy pertaining to drug discovery and development.

Experience:
6-8 years academic research experience in cancer biology (brain and breast tumors) and human genetics field.

Education:
Highest Degree : Ph.D

Affiliations:
Roswellpark Cancer Institute, University of Buffalo, NY

Skills:
Technical Experience

� Molecular biology techniques (Nucleic Acid Isolations, RT-PCR, Genomic PCR, Nested PCR, Real-time PCR, Primer designing, Radio-labeling, Southern blots, Northern blots, cDNA Cloning, Transformations, Restriction Fragment Length Polymorphisms (RFLP), Single Strand Conformation Polymorphisms (SSCP), Start-Site Mapping, Sequencing, Site-directed Mutagenesis, RNA protection Assay, GST pull down Assay, siRNA knock down experiments, Chromatin Immunoprecipitation (ChIP Assay) and Re-ChIP Assays, promoter hypermethylation

� Cell culture and drug treatments

� FACS Analysis

� Transfections

� Mammalian Expression and stable clone development

� Luciferase Assays

� Electrophoresis, Westerns, Co-immunoprecipitations, Elisa, Immuno-histochemistry

� Zymograms

� Electrophoretic Mobility Shift Assay (Gel Shift)

� Activity Assays

� Cytogenetics: Chromosomal preparation, In situ hybridization

� Invasion Assays

� Adeno-viral gene delivery

� Cryo sectioning

� Bio-chemical Assays

� Radiation Experiments

Computer skills

Adobe Photoshop, Graph Pad, Bio-informatic Tools like GENBank, BLAST, Jelly Fish, FASTA, DNA restriction mapping, Vector NTI, Micosoft word, Power Point, Microsoft Excel.

Additional Information:
Present Title and Affiliation

2002-Current Research Affiliate. Department of Pharmacology & Therapeutics, Roswell Park Cancer Institute, Buffalo NY.

Research Focus Molecular mechanism underlying the p53-ER� interaction and effect of radiation and antiestrogens on this interaction, with a potential to unravel novel targets for preventive and therapeutic strategies in treatment of breast cancer.
Postdoctoral Training

2001-2002 Visiting Scholar. Department of Cancer Biology, School of Medicine, University of Illinois, Peoria. Worked on role of Tissue Factor Pathway Inhibitor-2 (TFPI-2) in human gliomas

1998-2001
Post-Doctoral Fellow. Department of Neurosurgery, M.D. Anderson Cancer Center, Houston, TX. Worked on the role of TFPI-2 in human gliomas. Focus was on the role of serine protease inhibitor (TFPI-2) in the invasive behavior and tumor regression by sense and antisense technology using in vitro and in vivo models.

1994-98 Research Associate. Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India. The research project was focused on molecular mutations in phenylketonuria and homocystinuria
Bibliography

(Total number of publications: 32)

1. Wensheng Liu, Santhi D. Konduri, Bijay M. Nayak, Sanjay Bansal, Sigrid a. Rajasekaran, Pratima Srivastava, Benny K. Abraham, Hiltrud Brauch, Peter Fritz, Sankunny M. Karuppayil, ayyappan K. Rajasekaran and Gokul M. Das. Repression of p53 function by direct interaction with oestrogen receptor a. (First three authors contributed equally). Cancer Cell -submitted

2. Santhi D. Konduri, Srivenugopal S Kalkunti, Niranjan Yanamandra, Francis Ali-Osman, Dzung H Dinh, William C Olivero, Meena Gujrai, and Jasti S Rao. Tissue Factor Pathway Inhibitor-2 (TFPI-2) CpG island hyper-methylation is responsible for the down regulation of TFPI-2 expression in human glioma cells Oncogene 2003; 22,4509-4516.

3. Niranjan Yanamandra, Mark A. Berhow, Santhi D Konduri, Dzung H. Dinh, William c. Olivero, Garth L. Nicolson and Jasti S. Rao. Triterpenoids from Glycine max decrease invasiveness and induce caspase-mediated cell death in human SNB19 glioma cells. Clinical & Experimental Metastasis 2003; 20: 375-383.

4. Santhi D. Konduri, Niranjan Yanamandra, Dzung H Dinh, William H Olivero, Meena Gujrati, Donald C. Foster, Walter Kisiel and Jasti S Rao. Physiological and Chemical inducers of Tissue Factor Pathway Inhibitor-2 in Human Glioma Cells. Int. J Oncology. 2003 Jun;22(6):1277-83.

5. Santhi D. Konduri, Yanamandra N, Siddique K, Joseph A, Dinh DH, Olivero WC, Gujarati M, Kouraklis G, Swaroop A, Kyritsis AP, Rao JS. Modulation of cystatin C expression impairs the invasive and tumorigenic potential of human glioblastoma cells. Oncogene. 2002 Dec 12;21(57):8705-12.

6. Santhi D. Konduri, Osman FA, Rao CN, Srinivas H, Yanamandra N, Tasiou A, Dinh DH, Olivero WC, Gujrati M, Foster DC, Kisiel W, Kouraklis G, Rao JS. Minimal and inducible regulation of Tissue Factor Pathway Inhibitor-2 (TFPI-2) in Human Gliomas. Oncogene 2002 Jan 31;21(6):921-8.

7. Santhi D. Konduri, Rao CN, Nirmala C, Anastasia T, Mohanam, S, Kin Y, Sajani SK, Fuller GN, Francis AO and Rao JS. A novel function of tissue factor pathway inhibitor-2 (TFPI-2) in Human Glioma invasion. Oncogene, 2001, 18; 20 (47): 6938-45

8. Santhi D. Konduri, A. Tasiou, N. Chandrasekar and J.S. Rao. Over expression of tissue factor pathway inhibitor-2 (TFPI-2) decreases the invasiveness of prostate cancer cells in vitro. Int. J Oncology. 2001, 18: 127-131.

9. Santhi D. Konduri, Sajani S Lakka, Anastasia Tasiou, Niranjan Yanamandra, Christopher S Gondi, Dzung H. Dinh, William C.Olivero, Meena Gujrati and Jasti S. Rao. Elevated levels of cathepsin B in human glioblastoma cell lines. Int J Oncol. 2001; 19 (3): 519-24.

10. Anastasia T, Santhi D. Konduri and Rao JS. A novel role of tissue factor pathway inhibitor-2 (TFPI-2) in apoptosis of malignant human gliomas. Int J Oncol. 2001; 19(3): 591-7

11. Santhi D. Konduri, Anastasis Tasiou, Nirmala Chandrasekar, Garth L. Nicolson and J.S. Rao. Role of tissue factor pathway inhibitor-2 (TFPI-2) in amelanotic melanoma (C-32) invasion. Clin.Exp.Metastasis, 2000; 18: 303-308.

12. S.S. Lakka, Santhi D. Konduri, S. Mohanam, G.L. Nicolson and J.S. Rao. In vitro modulation of human lung cancer cell line invasiveness by antisense cDNA of tissue pathway inhibitor-2. Clin Exp Metastasis, 2000; 18: 239-244.

13. Niranjan Yanamandra, Santhi D Konduri, Mohanam Sanjeeva and Jasti S Rao. Down regulation of Urokinase-type plasminogen activator receptor (uPAR) Induces caspase mediated cell death in human glioblastoma cell line. Clin Exp Metastasis. 2000; 18 (7): 611-615.

14. Rao, C.N., Sajani S. Lakka, Kin, Y., Santhi D. Konduri, Fuller, G., Mohanam, S. and J.S. Rao. Expression of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor inversely correlates with grade of malignancy in human glioma. Clin Cancer Res 2001; 7: 570-576.

15. Chandrasekar Nirmala, Sushma L Jasti, Raymond Sawaya, Anthanassios P. Kyritsis, Santhi D. Konduri, Francis Ali-Osman, Jasti S. Rao and Sanjeeva Mohanam. Effects of radiation on the levels of MMP-2, MMP-9, and TIMP-1 during morphogenic glial-endothelial cell interactions. Int. J. Cancer, 2000; 88: 766-771.

16. Santhi D Konduri, A. Radha Rama Devi and Paturu Kondaiah: Amplification of phenylalanine hydroxylase and cystathionine beta synthase transcripts in human peripheral lymphocytes by RT-PCR. Biochemistry & molecular biology international. 1998; 45 (4): 643-650.

17. Kondaiah, P and Santhi D Konduri.: PCR applications in the prenatal diagnosis of single gene disorders. In " A Handbook of Prenatal Diagnosis and Reproductive Genetics". Edited by Dr. Kamini A. Rao under the egis of the Federation of Obstetric and Gynaecological Societies of India. 1997; 89-98.

Reference:
upon request

Candidate Contact Information:

Name: Santhi Konduri
Street:	Phone: 716-510-0147
City: Buffalo	Fax: -
State: New York
Zip: 14209
Web Site: