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| Desired Industry: Biotech |
SpiderID: 20074 |
| Desired Job Location: Bothell, Washington |
Date Posted: 3/15/2008 |
| Type of Position: Full-Time Permanent |
Availability Date: |
| Desired Wage: |
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U.S. Work Authorization: Yes |
| Job Level: Experienced with over 2 years experience |
Willing to Travel: Yes, 25-50% |
| Highest Degree Attained: Doctoral |
Willing to Relocate: Yes |
Experience:
PROFESSIONAL EXPERIENCE:
GlaxoSmithKline, King of Prussia, PA Principle
Scientist
2005-current
Evaluated Direct Analysis in Real Time (DART)
source for intact analysis of various dosage forms
at GSK.
Trained and adhered to ICH Q&A, cGMP and
CMC protocols
Performed equipment development for
scientific instrumentation.
Investigated potential of ion mobility
spectrometry (IMS) at GSK.
Trained in GMP/GLP practices.
Performed design of experiment protocol with
experiments for DART.
Invented methods of analysis utilizing DART-
MS.
Utilized AccuTOF mass spectrometer (JEOL).
Managed project to investigate key compound
within research group for GSK.
Multivariate Analysis of Data-(SIMCA-P, Origin
7.5, GRAMS).
Computer skills (ISIS Desktop Isis Draw, Isis
Base, Isis Net, Citrix, Origin 7.5, Mass Center,
Scifinder, Axum, ChemDraw Ultra 10.0, Photoshop,
iWork, Microsoft office products, Reference
Manager, Endnote)
The Pennsylvania State University, University Park,
PA - Ph. D. Candidate
1999-2005 Doctoral Research
Time-of-Flight Secondary Ion Mass
Spectrometry (ToF-SIMS)
Proteomic analysis with ToF-SIMS
Experienced in troubleshooting, servicing and
repairing mass spectrometers
Cell Culture and analysis of the culture with
mass spectrometry
Experimental Design in High throughput
Screening Developed a method for ToF-SIMS
analysis of a combinatorial library with high
throughput screening utilizing a barcode based on
metal nanoparticles
Metal Nanoparticle Synthesis
Surface Analysis of Polyethylene Glycol (and
other biologically compatible polymers)
Particle Size Analysis (Transmission and
Scanning Electron Microscopy)
Ultra High Vacuum Science Techniques
Expertise in managing classrooms of
undergraduate students.
Upkeep and Maintenance of Ultra High Vacuum
Equipment
NMR experiments and training of students
Norquay Technology - Research, Development and
Quality Chemist
1997-1999
QA/QC Chemist: Infrared Spectroscopy, Gas,
Column, and Thin Layer Chromatography, High
Performance Liquid Chromatography, Color Testing,
pH Testing, Air-Sensitive Techniques, KF Titration
Development/Process/Production/Scale up
Chemist: Schlenk Line Techniques, Large Scale
Vacuum Atmospheric and Fractional Distillation,
Melt Crystallization of dimethylbenzothiazole, 50 L
fractional distillation of vinyl cyclic alkanes,
Executed operation of a continuous reactor of vinyl
cyclic alkanes, 10 vacuum fractional distillation of
dimethylbenzothiazole, Troubleshoot problems for
synthesis of 3-bromoproprionic acid at 100 Gallon
reactor scale, Improved process for 2,2,4,4-
tetrahydroxbenzophenone, Executed solubility
testing to determine an efficient method of
improvement of yield and recovery of alkyl-
sulfonates. Synthesis of small molecules to
determine scalability of process. Interpretation of
heteronuclear NMR
Education:
Ph.D. Chemistry, Degree January 2006. The
Pennsylvania State University, University Park, PA
Thesis Title: Analysis and Signal Enhancement of
Polymer Systems with Metal Nanoparticles Using
Time-of-Flight Secondary Ion Mass Spectrometry
(ToF-SIMS)
Thesis Advisor: Dr. Nicholas Winograd
1 year Graduate School in Materials Science and
Engineering, University of Maryland, College Park,
MD.
B.S. Chemistry, ACS Certified May 1996, Kings
College, Wilkes-Barre, PA
Affiliations:
American Chemical Society
American Society of Mass Spectrometry
Skills:
Expertise in large scale organic synthesis of small
molecules (smallest scale = 0.5 kg).
Evaluation of new analytical technology for
feasibility of use in industrial applications
Development of scientific equipment
Familiarity in NMR experiments including
various nuclei (19F, 31P, and 13C).
Experienced in troubleshooting, servicing and
repairing mass spectrometers
Analysis of proteins and polypeptides with
mass spectrometry
Performed cell culture
Heterogeneous catalyst synthesis and
characterization
Laboratory automation and computer-aided
chemistry.
Proficient in identifying technical needs and
implementation to improve performance and
productivity.
Polymer synthesis and analysis of these
polymers with mass spectrometry and infrared
spectroscopy
Analysis and characterization of
Polytetrafluoroethylene (PTFE, Teflon)
Synthesis of small molecules (2, 2, 4, 4-
tetrahydroxybenzophenone for example)
Strategic planning for utilization and
development of new technology
Time saving, cost effective analytical method
development
Created an analytical method which boosts
mass spectral information with an inexpensive
surface treatment.
Developed a process to reduce processing and
solvent costs by preventing oxidation of 2,2,4,4-
tetrahydroxybenzonphenone to the xanthone
byproduct.
Directed students and plant workers at
Norquay Technology
cGMP/GLP practices
Operation of AccuTOF and DART. DART
analysis of: powders in solid form, suspensions,
liquids, tablets.
Preparation of tablets for analysis with HPLC. .
ToF-SIMS analysis of samples, spin coating of
films onto substrates, nanoparticle deposition onto
different materials
Ultrahigh vacuum techniques,
Organic synthesis of small molecules, polymer
synthesis, Schlenk line techniques, large scale
vacuum atmospheric and Fractional distillation,
melt crystallization,
GC-FID, GC-MS, mercury dillatometry, FT-IR,
dispersion IR,
Dispersion Raman, NMR, mass spectrometry
(DART, ESI, APCI, SIMS),
Scanning electron microscopy, transmission
electron microscopy, profilometry, atomic force
microscopy, Light microscopy
Different forms of titrations,
Fluorimetry, flow cytometry,
Cell culture, sterile technique,
Fluorescence microscopy (direct and inverted),
Gel electrophoresis, cell counting, ELISA, DNA
extraction,
Solid phase extraction,
Microcontact printing, nanoparticle synthesis
Additional Information:
Silver Recognition and Reward, GlaxoSmithKline
(Lead contact between NAT and PDPD as well as
pazopanib analysis)
Bronze Scientific Excellence Award, GlaxoSmithKline
(Presentation to FDA) 2006
Harry and Catherine Dalalian Graduate Fellowship in
Organic Chemistry, Penn State University, 2005.
Summer Fellowship, National Institute of Standards
and Technology, 1996.
Summer Fellowship, National Institute of Mental
Health, 1994.
Reference:
Coulton Legge, PhD
Manager, Novel Analytical Technologies
GlaxoSmithKline
44 1920 8833836
Coulton.H.Legge@gsk.com
Coulton.legge@btinternet.com
Kennedy Chibwe, PhD, MBA
Director Novel Analytical Technology,
GlaxoSmithKline
Kennedy.m.chibwe@gsk.com
610-917-5959
kennedy.m.chibwe@gsk.com
Melissa Gomez
Senior Scientist, CASS
919-483-7072
Melissa.a.gomez@gsk.com
Candidate Contact Information:
| Name: Abigale Marcus |
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| Street: - |
Phone: 610 270-4534 |
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