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| Desired Industry: Biotech |
SpiderID: 15206 |
| Desired Job Location: Princeton, New Jersey |
Date Posted: 8/30/2007 |
| Type of Position: Full-Time Permanent |
Availability Date: |
| Desired Wage: |
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U.S. Work Authorization: Yes |
| Job Level: Experienced with over 2 years experience |
Willing to Travel: Yes, 25-50% |
| Highest Degree Attained: Doctoral |
Willing to Relocate: Yes |
Experience:
Zhijun Wu
zj1234508536@yahoo.com
609-356-9152
PROFESSIAONL BACKGROUND
Organic synthesis and medicinal chemistry in the area of drug discovery research
SUMMARY OF SKILLS
· More than 20 years of experience in medicinal chemistry research
· Design and synthesis of a variety of bioactive compounds, including natural products, heterocycles, b-lactams, carbohydrates, nucleosides, peptidomimetics, and many others
· Solid knowledge and training with strong hands-on experience in organic synthesis and medicinal chemistry dealing with complex and diversified molecules; highly self-motivated, creative, possessing strong problem-solving skills
· Familiar with the principles and practices of various technologies involved in the conventional rational drug design and the modern combinatorial chemistries
· Hands-on experience in instrumental analyses: 1D and 2D-NMR, EI/CI/FAB/ES-MS, HPLC, UPLC, LCMS, FTIR, UV and CD
· Hands-on experience in chemistry databases: Beilstein-Crossfire, Scifinder, Pubmed, and many others
· General NMR lab equipment maintenance
EXPERIENCE
2001-2006 Senior Research Scientist, Palatin Technologies, Cranbury, NJ
Design and synthesis of small molecules for anti-obesity drug discovery research
2000-2001 Visiting Research Scientist, Rutgers University, NJ
Synthesis of benzimidazoles, terbenimidazoles and benzocinnolines as novel anticancer agents (topoisomerase I inhibitors)
1999-2000 Senior research Scientist at Sarnoff Research Institute
Synthesis of small molecules for drug discovery research
1998-1999 Staff Scientist, Advanced ChemTech/Helios Pharmaceuticals, KY
Design and synthesis of a variety of combinatorial libraries using automatic solid phase synthesizer for lead compound identification
1995-1998 Postdoctoral Research Fellow, University of Michigan, Ann Arbor, MI
Nucleosides, Carbohydrates, and Heterocycles:
· Synthesis of fluorinated nucleoside analogs as potential anti-viral agents
· Design and synthesis of TCRB analogs with C-glycosidic bondings
· Glycosylation studies of camptothecin and etoposide as potential anti-solid tumor agents
· Synthesis of C-glycosidic bonding trisaccharide as novel anticancer agents
1990-1995 Ph.D. Research, University of Kansas, Lawrence, KS
Stereoselective synthesis of beta-lactams, and natural product derivatives; asymmetric synthetic methodology studies
· Asymmetric Staudinger reaction (ketene-imine cycloaddition)
· Paclitaxel derivatives using chiral beta-lactams/beta-amino acids as building blocks
· Beta-lactam-containing dipeptide mimics as novel protease inhibitors
1988-1989 Visiting Scholar at Faculty of Pharmaceutical Chemistry, University of Tokyo, Tokyo, Japan
· Synthesis of diethylstilbestrol derivatives as novel anticancer agents
1982-1988 Research Associate, Zhejiang Academy of Medical Sciences, Hangzhou, China
· Studies of norethindrone enanthate as long lasting female contraceptives
EDUCATION
Ph.D. Synthetic Medicinal Chemistry, University of Kansas, Lawrence, KS, 1995
B.S. College of Pharmacy, Zhejiang University, China, 1982
AFFILIATION
American Chemical Society, Divisions of Organic Chemistry and Medicinal Chemistry,
1993-present
Candidate Contact Information:
| Name: Zhijun Wu |
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| Street: - |
Phone: 609-356-9152 |
| City: - |
Fax: - |
| State: New Jersey |
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| Zip: 08536 |
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| Web Site: |
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